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Title: Transcription of T cell-related genes in teleost fish, and the European sea bass (Dicentrarchus labrax) as a model
Authors: Boschi, Ilenia
Randelli, Elisa
Buonocore, Francesco
Casani, Daniela
Bernini, Chiara
Fausto, Anna Maria
Scapigliati, Giuseppe
Keywords: Fish immunology;Marine biotechnology;Aquaculture
Issue Date: 2011
Publisher: Elsevier
Source: Boschi, I. et al. 2011. Transcription of T cell-related genes in teleost fish, and the European sea bass (Dicentrarchus labrax) as a model. "Fish and Shellfish Immunology" 31 (5): 665-662
In recent years the cloning of genes coding for immuno-regulatory peptides, as well as the sequencing of genomes, provided fish immunologists with a growing amount of information on nucleotide sequences. Research is now also addressed in investigating the functional immunology counterpart of nucleotide sequence transcripts in various fish species. In this respect, studies on functional immunology of T cell activities are still at their beginning, and much work is needed to investigate T cell responses in teleost fish species.
In this review we summarise the current knowledge on the group of genes coding for main T cell-related peptides in fish, and the expression levels of these genes in organs and tissues. Particular attention is paid to European sea bass (Dicentrarchus labrax), a marine species in which some information on functional immunology has been obtained, and we reassume here the expression of some T cell-related genes in basal conditions. In addition, we provide original data showing that T cells purified from the intestinal mucosa of sea bass with a specific mAb, express transcripts for TRgamma, TRbeta, CDalpha and RAG-1, thus showing similarities with intraepithelial leucocytes of mammals.
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ISSN: 1050-4648
DOI: 10.1016/j.fsi.2010.10.001
Appears in Collections:DISA - Archivio della produzione scientifica

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