Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/2067/2068
Titolo: | Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells | Autori: | Belfiore, Maria Cristina Natoni, Alessandro Barzellotti, Roberta Merendino, Nicolò Pessina, Gloria Gualandi, Giampiero |
Parole chiave: | Apoptosis;LOXs | Data pubblicazione: | 2007 | Editore: | Elsevier | Fonte: | Belfiore, M. C. et al. 2007. Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells. "Cancer Letters" 254 (2): 236-243 | Abstract: | Epstein–Barr Virus (EBV) is involved in the progression of lymphomas through still unknown mechanism involving increased resistance to induced apoptosis. We show here that in a set of apoptosis-resistant EBV-converted Burkitt’s lymphoma clones, 5- and 12-lipoxygenases (LOXs) are over-expressed. Further investigations on 5-LOX showed that resistance to apoptosis increases parallely with the expression of 5-lipoxygenase (5-LOX). Inhibitors of 5-LOX: (a) decrease peroxides level, indicating that this enzyme promotes the generation of oxidative stress in EBV+ cells, and (b) potently induce apoptosis in the EBV resistant cell line E2R. 5- and 15-HETE, the products of the 5 and 15-LOXs, respectively, counteract 5-LOX inhibitor induced apoptosis, indicating that products of arachidonate metabolism, rather than peroxides, trigger a signal transduction that is required for survival of the EBV-converted cells. These findings suggest that 5- and, to a lesser extent, other LOXs, that are involved in tumor progression of several cell types, may also participate in lymphomagenesis, especially that EBV-mediated. |
Acknowledgments: | L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com |
URI: | http://hdl.handle.net/2067/2068 | ISSN: | 0304-3835 | DOI: | 10.1016/j.canlet.2007.03.010 |
È visualizzato nelle collezioni: | DECOS - Archivio della produzione scientifica |
File in questo documento:
File | Descrizione | Dimensioni | Formato | |
---|---|---|---|---|
CancerLetters2068.pdf | 64.08 kB | Adobe PDF | Visualizza/apri |
SCOPUSTM
Citations
10
18
Last Week
0
0
Last month
0
0
controllato il 5-nov-2021
Page view(s)
238
Last Week
0
0
Last month
6
6
controllato il 20-apr-2024
Download(s)
201
controllato il 20-apr-2024
Google ScholarTM
Check
Altmetric
Tutti i documenti nella community "Unitus Open Access" sono pubblicati ad accesso aperto.
Tutti i documenti nella community Prodotti della Ricerca" sono ad accesso riservato salvo diversa indicazione per alcuni documenti specifici