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Title: Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells
Authors: Belfiore, Maria Cristina
Natoni, Alessandro
Barzellotti, Roberta
Merendino, Nicolò
Pessina, Gloria
Gualandi, Giampiero
Keywords: Apoptosis;LOXs
Issue Date: 2007
Publisher: Elsevier
Source: Belfiore, M. C. et al. 2007. Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells. "Cancer Letters" 254 (2): 236-243
Epstein–Barr Virus (EBV) is involved in the progression of lymphomas through still unknown mechanism involving
increased resistance to induced apoptosis. We show here that in a set of apoptosis-resistant EBV-converted Burkitt’s lymphoma clones, 5- and 12-lipoxygenases (LOXs) are over-expressed. Further investigations on 5-LOX showed that resistance to apoptosis increases parallely with the expression of 5-lipoxygenase (5-LOX). Inhibitors of 5-LOX: (a) decrease peroxides level, indicating that this enzyme promotes the generation of oxidative stress in EBV+ cells, and (b) potently induce apoptosis in the EBV resistant cell line E2R. 5- and 15-HETE, the products of the 5 and 15-LOXs, respectively,
counteract 5-LOX inhibitor induced apoptosis, indicating that products of arachidonate metabolism, rather than peroxides, trigger a signal transduction that is required for survival of the EBV-converted cells. These findings suggest that 5- and, to a lesser extent, other LOXs, that are involved in tumor progression of several cell types, may also participate in lymphomagenesis, especially that EBV-mediated.
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ISSN: 0304-3835
DOI: 10.1016/j.canlet.2007.03.010
Appears in Collections:DECOS - Archivio della produzione scientifica

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