Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1880
DC FieldValueLanguage
dc.contributor.authorMurgiano, Leonardo-
dc.contributor.authorTimperio, Anna Maria-
dc.contributor.authorZolla, Lello-
dc.contributor.authorBongiorni, Silvia-
dc.contributor.authorValentini, Alessio-
dc.contributor.authorPariset, Lorraine-
dc.date.accessioned2011-04-06T09:36:38Z-
dc.date.available2011-04-06T09:36:38Z-
dc.date.issued2011-04-06-
dc.identifier.issn2072-6643-
dc.identifier.urihttp://hdl.handle.net/2067/1880-
dc.description.abstractIdentification of proteins involved in milk production is important to understand the biology of lactation. Many studies have advanced the understanding of mammary function and milk secretion, but the critical molecular mechanisms implicated in milk fat secretion is still incomplete. Milk Fat Globules are secreted from the apical surface of the mammary cells, surrounded by a thin membrane bilayer, the Milk Fat Globule Membrane (MFGM), formed by proteins which have been suggested to be holesterolemia-lowering factors, inhibitors of cancer cell growth, vitamin binders, bactericidal, suppressors of multiple sclerosis. Using a proteomic approach, we compared MFGM from milk samples of individuals belonging to two different cattle breeds, Chianina and Holstein,representative of selection for milk and meat traits, respectively. We were able to isolate some of the major MFGM proteins in the examined samples and to identify differences between the protein fractions of the two breeds. We detected differences in the amount of proteins linked to mammary gland development and lipid droplets formation, as well as host defence mechanisms. We have shown that proteomics is a suitable, unbiased method for the study of milk fractions proteins and a powerful tool in nutritional genomics.it
dc.language.isoenit
dc.subjectmilk proteomicsit
dc.subjectproteomica del latteit
dc.subjectMFGMit
dc.subjectMFGMit
dc.subjectcattleit
dc.subjectbestiameit
dc.subjectlactationit
dc.subjectlattazioneit
dc.subjectMS/MSit
dc.subjectMS/MSit
dc.titleComparison of Milk Fat Globule Membrane (MFGM) Proteins of Chianina and Holstein Cattle Breed Milk Samples Through Proteomics Methodsit
dc.typeArticleit
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
Appears in Collections:DiPA - Archivio della produzione scientifica
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