Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1877
Title: Telomere length diversity in cattle breeds
Authors: Tilesi, Francesca
Di Domenico, Enea Gino
Pariset, Lorraine
Bosco, Luigi
Willems, Daniela
Valentini, Alessio
Ascenzioni, Fiorentina
Keywords: Lunghezza dei Telomeri;Telomere length;Razze Bovine;Cattle Breed;Chianina;Chianina;Maremmana;Maremmana
Issue Date: 5-Apr-2011
Abstract: 
Telomeres are specialized nucleoprotein structures that have two important functions: (i) protection of the chromosomal ends from deleterious events such as chromosome fusion and degradation; (ii) counteraction of the “end replication problem” by allowing telomerase-dependent or, more rarely, telomerase-independent telomere elongation. The DNA sequences underlying these activities are short simple tandem repeats, which in vertebrate consist of a variable number of TTAGGG. Telomeres dysfunction may be caused either by the absence of telomerase activity or by mutations in telomeric proteins nvolved in telomere length and structure regulation. Additionally,increasing experimental evidence suggests that telomeres take part in the complex network regulating cell roliferation. Accordingly, telomeres are involved in biological process such as aging and tumor progression. In this study we determined the telomere length in two bovine Italian cattle breeds, Chianina and Maremmana, which are characterized by high longevity and range breeding. In order to account for possible variation among different tissues, we have determined telomere length in different organs such as spleen,lung and liver. Overall, the median telomere length was significant lower in Chianina
(11 ± 0.69 kb) than in Maremmana (12.05 ± 1.57 kb). Moreover, telomere length variation
among individuals was very low in Chianina but rather high in Maremmana. These data
suggest that telomere length is influenced by the breeds. This hypothesis is confirmed by
the different history of these Italian breeds. Indeed, Chianina has a long history and its size was maintained by the Breeders Association without necessity to crossbreed with other breeds, whereas the population of Maremmana underwent a dramatic shrinkage in the recent past. Therefore, breeders have crossed Maremmana with other breeds, like Charolais, and have relaxed the rules for the inclusion in the herd book.
URI: http://hdl.handle.net/2067/1877
ISSN: 1424-2818
Appears in Collections:DiPA - Archivio della produzione scientifica

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