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Title: Proteomics and Transcriptomics Investigation on longissimus Muscles in Large White and Casertana Pig Breeds
Authors: Murgiano, Leonardo
D'Alessandro, Angelo
Egidi, Maria Giulia
Crisa, Alessandra
Prosperini, Gianluca
Timperio, Anna Maria
Zolla, Lello
Keywords: Casertana pig breed;Large white pig breed;Fat deposition;Interactomics;Proteomics
Issue Date: 2010
Publisher: American Chemical Society
Source: Murgiano, L. et al. 2010. Proteomics and Transcriptomics Investigation on Longissimus Muscles in Large White and Casertana Pig Breeds. "Journal of Proteome Research" 9(12): 6450-6466
Consumer complaints against the blandness of modern lean meat and the frequent reference to the
more strongly flavored meat that was available years ago have prompted reconsideration of high fatdepositing
typical pig breeds. Casertana and Large White pig breeds are characterized by a different
tendency toward fat accumulation as they exhibit opposite genetic and physiological traits with respect
to the energy metabolism. These physiological differences were investigated in longissimus lumborum
muscles through proteomics (2-DE, MS/MS) and microarray approaches. Data were analyzed for
pathway and network analyses, as well as GO term enrichment of biological functions. As a result,
Casertana showed a greater amount of proteins involved in glycolitic metabolism and mainly rely on
fast-mobilizable energy sources. Large White overexpressed cell cycle and skeletal muscle growth related
genes. Metabolic behavior and other implications are discussed.
L'articolo è disponibile sul sito dell'editore
ISSN: 1535-3893
DOI: 10.1021/pr100693h
Appears in Collections:DISA - Archivio della produzione scientifica

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