Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1821
Title: The role of the formamide/zirconia system in the synthesis of nucleobases and biogenic carboxylic acid derivatives
Authors: Saladino, Raffaele
Neri, Veronica
Crestini, Claudia
Costanzo, Giovanna
Graciotti, Michele
Di Mauro, Ernesto
Keywords: Carboxylic acids;Formamide;Nucleic acids stability;;Pyrimidines;Purines;Zirconium derivatives
Issue Date: 2010
Publisher: Springer-Verlag
Source: Saladino, R. et al. 2010. The role of the formamide/zirconia system in the synthesis of nucleobases and biogenic carboxylic acid derivatives. "Journal of Molecular Evolution" 71(2): 100-110.
Abstract: 
We describe the one-pot synthesis of a large variety of nucleic acid bases and related compounds from formamide in the presence of zirconium minerals as catalysts. The major products observed are: purine, 2-hydroxy pyrimidine, 5-hydroxy pyrimidine, isocytosine, adenine, urea, and carbodiimide. The synthesis of low molecular weight amides and carboxylic acid derivatives (intermediates of extant metabolism) was also observed: glyoxylamide, glycolic-, lactic-, succinic-, oxalic-, fumaric-, and maleic acids. As the major problem in the origin of informational polymers is the instability of their precursors, we also investigated the effects of zirconia minerals on the stability of ribooligonucleotides in formamide and in water. The relevance of these findings with respect to the origin of informational polymers and primordial metabolism is discussed.
Description: 
L'articolo é disponibile sul sito dell'editore: http://www.springerlink.com
URI: http://hdl.handle.net/2067/1821
ISSN: 0022-2844
Appears in Collections:DABAC - Archivio della produzione scientifica

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