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Title: Chromosome radiosensitivity in human G2 lymphocytes and cell cycle progression
Authors: Palitti, Fabrizio
Pichierri, Pietro
Franchitto, Annapaola
Proietti De Santis, Luca
Mosesso, Pasquale
Issue Date: 1999
Publisher: Informa Healthcare
Source: Palitti, F. et al. 1999. Chromosome radiosensitivity in human G2 lymphocytes and cell cycle progression. "International Journal of Radiation Biology" 75(5): 621-627
PURPOSE: To investigate the possibility that the differential G2-phase radiosensitivity of human peripheral blood lymphocytes, found in normal individuals using the 'G2-phase chromosome radiosensitivity assay', could be attributed to heterogeneity in cellular progression to mitosis rather than differences in radiosensitivity.

MATERIALS AND METHODS: Human peripheral blood lymphocytes, from four different donors, were exposed to 50 cGy X-rays and sampled at different times. The progression of cells into mitosis was monitored by 5-bromo 2'-deoxyuridine (BrdUrd) incorporation.

RESULTS: The heterogeneous G2-phase chromosome radiosensitivity among different donors was abolished when homogeneous G2-phase cell populations were scored; they contained similar frequencies of cells in early or late G2-phase.

CONCLUSIONS: The heterogeneous G2-phase chromosome radiosensitivity, usually found in different normal donors, is caused by the analysis of different cell populations rather than reflecting intrinsic differences in radiosensitivity
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ISSN: 0955-3002
Appears in Collections:DABAC - Archivio della produzione scientifica

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