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Title: Influence of DMSO on Carbon K ultrasoft X-rays induced chromosome aberrations in V79 Chinese hamster cells
Authors: Natarajan, Adayapalam T.
Palitti, Fabrizio
Hill, Mark A.
Stevens, David L.
Ahnström, Gunnar
Keywords: Ultrasoft X-rays;DMSO;Chromosomal aberrations
Issue Date: 2010
Publisher: Elsevier
Source: Natarajan, A.T. et al. 2010. Influence of DMSO on Carbon K ultrasoft X-rays induced chromosome aberrations in V79 Chinese hamster cells. "Mutation Research" 691(1-2): 23-26
Ultrasoft X-rays have been shown to be very efficient in inducing chromosomal aberrations in mammalian cells. The present study was aimed to evaluate the modifying effects of DMSO (a potent scavenger of free radicals) on the frequencies of chromosome aberrations induced by soft X-rays. Confluent held G1 Chinese hamster cells (V79) were irradiated with Carbon K ultrasoft X-rays in the presence and absence of 1 M DMSO and frequencies of chromosome aberrations in the first division cells were determined. DMSO reduced the frequencies of exchange types of aberrations (dicentrics and centric rings) by a factor of 2.1–3.5. The results indicate that free radicals induced by ultrasoft X-rays contribute to a great extent to the induction of chromosome aberrations. The possible implications of these results in interpreting the mechanisms involved in the high efficiency of ultrasoft X-rays in the induction of chromosome aberrations are discussed.
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DOI: 10.1016/j.mrfmmm.2010.06.008
Appears in Collections:DABAC - Archivio della produzione scientifica

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