Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1662
DC FieldValueLanguage
dc.contributor.authorCostantini, Susan-
dc.contributor.authorBuonocore, Francesco-
dc.contributor.authorFacchiano, Angelo M.-
dc.date.accessioned2011-03-24T14:56:19Z-
dc.date.available2011-03-24T14:56:19Z-
dc.date.issued2011-
dc.identifier.citationCostantini, S., Buonocore, F., Facchiano, A.M. 2008. Molecular modelling of co-receptor CD8αα and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata). "Fish and Shellfish Immunology" 25(6): 782-790it
dc.identifier.issn1050-4648-
dc.identifier.urihttp://hdl.handle.net/2067/1662-
dc.descriptionL'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com/it
dc.description.abstractT-cells are the main actors of cell-mediated immune defence; they recognize and respond to peptide antigens associated with MHC class I and class II molecules. In this paper, we investigated by molecular modelling methods in the teleost sea bream (Sparus aurata) the interaction among the molecules of the tertiary complex CD8/MHC-I/TCR, which determines the T-cell-mediated immunological response to foreign molecules. First, we predicted the three-dimensional structure of CD8αα dimer and MHC-I, and, successively, we simulated the CD8αα/MHC-I complex. Finally, the 3D structure of the CD8/MHC-I/TCR complex was simulated in order to investigate the possible changes that can influence TCR signalling events.it
dc.language.isoenit
dc.publisherElsevierit
dc.subjectFish Immunologyit
dc.subjectMolecular Biologyit
dc.subjectSparus auratait
dc.subjectMolecular modellingit
dc.subjectProtein structureit
dc.subjectCD8it
dc.subjectT-cell receptorit
dc.subjectMHC-Iit
dc.titleMolecular modelling of co-receptor CD8αα and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata)it
dc.typeArticleit
dc.identifier.doi10.1016/j.fsi.2008.03.020it
item.grantfulltextopen-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.languageiso639-1en-
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