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Title: Molecular modelling of co-receptor CD8αα and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata)
Authors: Costantini, Susan
Buonocore, Francesco
Facchiano, Angelo M.
Keywords: Fish Immunology;Molecular Biology;Sparus aurata;Molecular modelling;Protein structure;CD8;T-cell receptor;MHC-I
Issue Date: 2011
Publisher: Elsevier
Source: Costantini, S., Buonocore, F., Facchiano, A.M. 2008. Molecular modelling of co-receptor CD8αα and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata). "Fish and Shellfish Immunology" 25(6): 782-790
T-cells are the main actors of cell-mediated immune defence; they recognize and respond to peptide antigens associated with MHC class I and class II molecules. In this paper, we investigated by molecular modelling methods in the teleost sea bream (Sparus aurata) the interaction among the molecules of the tertiary complex CD8/MHC-I/TCR, which determines the T-cell-mediated immunological response to foreign molecules. First, we predicted the three-dimensional structure of CD8αα dimer and MHC-I, and, successively, we simulated the CD8αα/MHC-I complex. Finally, the 3D structure of the CD8/MHC-I/TCR complex was simulated in order to investigate the possible changes that can influence TCR signalling events.
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ISSN: 1050-4648
DOI: 10.1016/j.fsi.2008.03.020
Appears in Collections:DISA - Archivio della produzione scientifica

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