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http://hdl.handle.net/2067/1581| Title: | Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells | Authors: | Bernini, Roberta Crisante, Fernanda Merendino, Nicolò Molinari, Romina Soldatelli, Maria Chiara Velotti, Francesca Romana |
Keywords: | Polyphenols;Antitumor;Colon cancer | Issue Date: | 2010 | Publisher: | Imprim Vert | Source: | Bernini, R. et al. 2010 Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells. In: Ageorges, A. et al. (a cura di). Polyphenols Communications 2010. XXVth International Conference on Polyphenols (Montpellier, 24-27 August 2010). Montpellier, Imprim Vert, pp. 98-99 | Abstract: | A novel hydroxytyrosol-lipoic acid derivative has been synthesized. Key steps are an esterification reaction between tyrosol and cJipoic acid derivatives and a regioselective aromatic hydroxylation ofthe monohydroxylated ester performed by 2-iodoxybenzoic acid (IBX) followed by an in situ reductionw ith sodium dithionite (Na2S2O4T).h e novel estere xhibited an antiproliferative effect on the human colorectal adenocarcinoma HT-29 cell line signifrcantly more potent than its parent compounds. |
URI: | http://hdl.handle.net/2067/1581 | ISBN: | 978-2-7388-1282-1 |
| Appears in Collections: | DECOS - Archivio della produzione scientifica |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Montpellier T1.08.PDF | 2.33 MB | Adobe PDF | View/Open |
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