Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells

Bernini, Roberta; Crisante, Fernanda; Merendino, Nicolò; Molinari, Romina; Soldatelli, Maria Chiara; Velotti, Francesca Romana

UnitusOpen

Welcome in UnitusOpen, the institutional repository and open access archive of the University of Tuscia.
UnitusOpen is the official channel of the University of Tuscia for collecting, archiving, and disseminating the scientific outputs of the researchers. Visitors of UnitusOpen may get access to open scientific outputs disseminated in accordance with the European requirements of Open Access or enter in contact with researchers for requesting information about their publications.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1581

DC Field	Value	Language
dc.contributor.author	Bernini, Roberta	-
dc.contributor.author	Crisante, Fernanda	-
dc.contributor.author	Merendino, Nicolò	-
dc.contributor.author	Molinari, Romina	-
dc.contributor.author	Soldatelli, Maria Chiara	-
dc.contributor.author	Velotti, Francesca Romana	-
dc.date.accessioned	2011-03-22T23:18:01Z	-
dc.date.available	2011-03-22T23:18:01Z	-
dc.date.issued	2010	-
dc.identifier.citation	Bernini, R. et al. 2010 Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells. In: Ageorges, A. et al. (a cura di). Polyphenols Communications 2010. XXVth International Conference on Polyphenols (Montpellier, 24-27 August 2010). Montpellier, Imprim Vert, pp. 98-99	it
dc.identifier.isbn	978-2-7388-1282-1	-
dc.identifier.uri	http://hdl.handle.net/2067/1581	-
dc.description.abstract	A novel hydroxytyrosol-lipoic acid derivative has been synthesized. Key steps are an esterification reaction between tyrosol and cJipoic acid derivatives and a regioselective aromatic hydroxylation ofthe monohydroxylated ester performed by 2-iodoxybenzoic acid (IBX) followed by an in situ reductionw ith sodium dithionite (Na2S2O4T).h e novel estere xhibited an antiproliferative effect on the human colorectal adenocarcinoma HT-29 cell line signifrcantly more potent than its parent compounds.	it
dc.language.iso	en	it
dc.publisher	Imprim Vert	it
dc.subject	Polyphenols	it
dc.subject	Antitumor	it
dc.subject	Colon cancer	it
dc.title	Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells	it
dc.type	Conference Proceedings	it
local.message.claim	2021-11-08T15:56:29.902+0100\|\|\|rp00176\|\|\|submit_approve\|\|\|dc_contributor_author\|\|\|None	*
item.fulltext	With Fulltext	-
item.openairetype	Conference Proceedings	-
item.cerifentitytype	Publications	-
item.grantfulltext	open	-
item.languageiso639-1	en	-
item.openairecristype	http://purl.org/coar/resource_type/c_18cf	-
Appears in Collections:	DECOS - Archivio della produzione scientifica

Files in This Item:

File	Description	Size	Format
Montpellier T1.08.PDF		2.33 MB	Adobe PDF	View/Open

Show simple item record

Page view(s)

202

Last Week
0

Last month
4

checked on Apr 17, 2024

Download(s)

127

checked on Apr 17, 2024

Google Scholar^TM

Check

Altmetric

All documents in the "Unitus Open Access" community are published as open access.
All documents in the community "Prodotti della Ricerca" are restricted access unless otherwise indicated for specific documents