Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1581
Title: Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells
Authors: Bernini, Roberta
Crisante, Fernanda
Merendino, Nicolò
Molinari, Romina
Soldatelli, Maria Chiara
Velotti, Francesca Romana
Keywords: Polyphenols;Antitumor;Colon cancer
Issue Date: 2010
Publisher: Imprim Vert
Source: Bernini, R. et al. 2010 Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells. In: Ageorges, A. et al. (a cura di). Polyphenols Communications 2010. XXVth International Conference on Polyphenols (Montpellier, 24-27 August 2010). Montpellier, Imprim Vert, pp. 98-99
Abstract: 
A novel hydroxytyrosol-lipoic acid derivative has been synthesized. Key steps are an
esterification reaction between tyrosol and cJipoic acid derivatives and a regioselective aromatic
hydroxylation ofthe monohydroxylated ester performed by 2-iodoxybenzoic acid (IBX) followed by an
in situ reductionw ith sodium dithionite (Na2S2O4T).h e novel estere xhibited an antiproliferative effect on
the human colorectal adenocarcinoma HT-29 cell line signifrcantly more potent than its parent compounds.
URI: http://hdl.handle.net/2067/1581
ISBN: 978-2-7388-1282-1
Appears in Collections:DECOS - Archivio della produzione scientifica

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