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http://hdl.handle.net/2067/1571| Title: | Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells | Authors: | Bernini, Roberta Crisante, Fernanda Merendino, Nicolò Molinari, Romina Soldatelli, Maria Chiara Velotti, Francesca Romana |
Keywords: | Hydroxytyrosol;Lipoic acid;New ester;Antiproliferative effect;HT-29 cells | Issue Date: | 2010 | Publisher: | Imprim Vert | Source: | Bernini, R. et al. 2010 Synthesis of a novel ester of hydroxytyrosol and lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells. In: Ageorges, A. et al. (a cura di). XXV Th International Conference on Polyphenols. Polyphenols Communications 2010. (Montpellier, France 24-27 August). 1: 98-99 | Abstract: | A novel hydroxytyrosol-lipoic acid derivative has been synthesized. Key steps are an esterification reaction between tyrosol and -lipoic acid derivatives and a regioselective aromatic hydroxylation of the monohydroxylated ester performed by 2-iodoxybenzoic acid (IBX) followed by an in situ reduction with sodium dithionite (Na2S2O4). The novel ester exhibited an antiproliferative effect on the human colorectal adenocarcinoma HT-29 cell line significantly more potent than its parent compounds |
URI: | 978-2-7380-1282-1 http://hdl.handle.net/2067/1571 |
| Appears in Collections: | DABAC - Archivio della produzione scientifica |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Montpellier T1.08.PDF | 2.33 MB | Adobe PDF | View/Open |
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