Please use this identifier to cite or link to this item:
Title: Physiology and pathology of somatostatin in the mammalian retina: a current view
Authors: Cervia, Davide
Casini, Giovanni
Bagnoli, Paola
Keywords: Somatostatin receptors;Signalling mechanisms;Somatostatin analogues;Retinal ischemia;Diabetic retinopathy
Issue Date: 2008
Publisher: Elsevier
Source: Cervia, D., Casini, G., Bagnoli, P. 2008. Physiology and pathology of somatostatin in the mammalian retina: a current view. "Molecular and Cellular Endocrinology" 286(1-2):112-122
In the retina, peptidergic signalling participates in multiple circuits of visual information processing. The neuropeptide somatostatin (SRIF) is localised to amacrine cells and, in some instances, in a subset of ganglion cells. The variegated expression patterns of SRIF receptors (sst1-sst5) and the variety of signalling mechanisms activated by retinal SRIF suggest that this peptide may exert multiple actions on retinal neurons and on retinal physiology, although our current understanding reflects a rather complicated picture. SRIF, mostly through sst2, may act as a positive factor in the retina by regulating retinal homeostasis and protecting neurons against damage. In this respect, SRIF analogues seem to constitute a promising therapeutic arsenal to cure different retinal diseases, as for instance ischemic and diabetic retinopathies. However, further investigations are needed not only to fully understand the functional role of the SRIF system in the retina but also to exploit new chemical space for drug-like molecules.
L'articolo è disponibile sul sito dell'editore
ISSN: 0303-7207
DOI: 10.1016/j.mce.2007.12.009
Appears in Collections:DISA - Archivio della produzione scientifica

Files in This Item:
File Description SizeFormat
Cervia et al 2008.pdf398.2 kBAdobe PDFView/Open
Show full item record

Page view(s)

Last Week
Last month
checked on Oct 24, 2020


checked on Oct 24, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.