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http://hdl.handle.net/2067/1476| Title: | Interleukin 18 in the CNS | Authors: | Alboni, Silvia Cervia, Davide Sugama, Shuei Conti, Bruno |
Issue Date: | 2010 | Publisher: | BioMed Central | Source: | Alboni, S. et al. 2010. Interleukin 18 in the CNS. "Journal of Neuroinflammation" 7:9 | Abstract: | Interleukin (IL)-18 is cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behaviour. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease. |
Description: | L'articolo è disponibile sul sito dell'editore http://www.biomedcentral.com/ |
URI: | http://hdl.handle.net/2067/1476 | ISSN: | 1742-2094 | DOI: | 10.1186/1742-2094-7-9 |
| Appears in Collections: | DISA - Archivio della produzione scientifica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Alboni et al 2010 J Neuroinflammation 1.pdf | 137.97 kB | Adobe PDF | View/Open |
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