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Title: Mapping of the full length and the truncated interleukin-18 receptor alpha transcripts in the mouse brain
Authors: Alboni, Silvia
Cervia, Davide
Ross, Brendon
Montanari, Claudia
Sanchez-Gonzales, Alejandro
Sanchez-Alavez, Manuel
Garibaldi-Marcondes, Maria Cecilia
De Vries, David
Sugama, Shuei
Brunello, Nicoletta
Blom, Joan
Tascedda, Fabio
Conti, Bruno
Keywords: Interleukin;Receptor;IL-18;IL-18R;Isoform;Brain
Issue Date: 2009
Publisher: Elsevier
Source: Alboni, S. et al. 2009. Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain. "Journal of Neuroimmunology" 214(1-2): 43-54
The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Rα\β. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Rα transcripts, a full length and an isoform lacking the intracellular domain
hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.
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ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2009.06.016
Appears in Collections:DISA - Archivio della produzione scientifica

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