Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1469
DC FieldValueLanguage
dc.contributor.authorTrielli, Francescait
dc.contributor.authorCervia, Davideit
dc.contributor.authorDi Giuseppe, Grazianoit
dc.contributor.authorRistori, Chiarait
dc.contributor.authorKruppel, Thomasit
dc.contributor.authorBurlando, Brunoit
dc.contributor.authorGuella, Grazianoit
dc.contributor.authorViarengo, Aldoit
dc.contributor.authorBagnoli, Paolait
dc.contributor.authorDelmonte Corrado, Maria Umbertait
dc.contributor.authorDini, Fernandoit
dc.date.accessioned2011-03-21T13:37:06Zit
dc.date.available2011-03-21T13:37:06Zit
dc.date.issued2008it
dc.identifier.citationTrielli, F. et al. 2008. Action Mechanisms of the Secondary Metabolite Euplotin C: Signaling and Functional Role in Euplotes. "Journal of Eukaryotic Microbiology" 55 (5): 365-373it
dc.identifier.issn1066-5234it
dc.identifier.urihttp://hdl.handle.net/2067/1469it
dc.descriptionL'articolo è disponibile sul sito dell'editore http://onlinelibrary.wiley.com/it
dc.description.abstractAmong secondary metabolites, the acetylated hemiacetal sesquiterpene euplotin C has been isolated from the marine, ciliated protist Euplotes crassus, and provides an effective mechanism for reducing populations of potential competitors through its cytotoxic properties. However, intracellular signaling mechanisms and their functional correlates mediating the ecological role of euplotin C are largely unknown. We report here that, in E. vannus (an Euplotes morphospecies which does not produce euplotin C and shares with E. crasssus the same interstitial habitat), euplotin C rapidly increases the intracellular concentration of both Ca2+ and Na+, suggesting a generalized effect of this metabolite on cation transport systems. In addition, euplotin C does not induce oxidative stress, but modulates the electrical properties of E. vannus through an increase of the amplitude of graded action potentials. These events parallel the disassembling of the ciliary structures, the inhibition of cell motility, the occurrence of aberrant cytoplasmic vacuoles, and the rapid inhibition of phagocytic activity. Euplotin C also increases lysosomal pH and decreases lysosomal membrane stability of E. vannus. These results suggest that euplotin C exerts a marked disruption of those homeostatic mechanisms whose efficiency represents the essential prerequisite to face the challenges of the interstitial environmental.it
dc.language.isoenit
dc.publisherWiley-Blackwellit
dc.subjectAction potentialsit
dc.subjectCation homeostasisit
dc.subjectCiliated protistsit
dc.subjectLysosomesit
dc.subjectMarine microorganismsit
dc.subjectOxidative stressit
dc.subjectPhagocytosisit
dc.subjectSesquiterpenoidsit
dc.titleAction Mechanisms of the Secondary Metabolite Euplotin C: Signaling and Functional Role in Euplotesit
dc.typeArticleit
dc.identifier.doi10.1111/j.1550-7408.2008.00335.xit
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:DISA - Archivio della produzione scientifica
Files in This Item:
File Description SizeFormat
Trielli et al J Euk Microbiol 2008 1.pdf41.55 kBAdobe PDFView/Open
Show simple item record

SCOPUSTM   
Citations 10

10
Last Week
0
Last month
1
checked on Sep 18, 2023

Page view(s)

124
Last Week
0
Last month
0
checked on Mar 27, 2024

Download(s)

84
checked on Mar 27, 2024

Google ScholarTM

Check

Altmetric


All documents in the "Unitus Open Access" community are published as open access.
All documents in the community "Prodotti della Ricerca" are restricted access unless otherwise indicated for specific documents