Please use this identifier to cite or link to this item:
http://hdl.handle.net/2067/1469
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Trielli, Francesca | it |
dc.contributor.author | Cervia, Davide | it |
dc.contributor.author | Di Giuseppe, Graziano | it |
dc.contributor.author | Ristori, Chiara | it |
dc.contributor.author | Kruppel, Thomas | it |
dc.contributor.author | Burlando, Bruno | it |
dc.contributor.author | Guella, Graziano | it |
dc.contributor.author | Viarengo, Aldo | it |
dc.contributor.author | Bagnoli, Paola | it |
dc.contributor.author | Delmonte Corrado, Maria Umberta | it |
dc.contributor.author | Dini, Fernando | it |
dc.date.accessioned | 2011-03-21T13:37:06Z | it |
dc.date.available | 2011-03-21T13:37:06Z | it |
dc.date.issued | 2008 | it |
dc.identifier.citation | Trielli, F. et al. 2008. Action Mechanisms of the Secondary Metabolite Euplotin C: Signaling and Functional Role in Euplotes. "Journal of Eukaryotic Microbiology" 55 (5): 365-373 | it |
dc.identifier.issn | 1066-5234 | it |
dc.identifier.uri | http://hdl.handle.net/2067/1469 | it |
dc.description | L'articolo è disponibile sul sito dell'editore http://onlinelibrary.wiley.com/ | it |
dc.description.abstract | Among secondary metabolites, the acetylated hemiacetal sesquiterpene euplotin C has been isolated from the marine, ciliated protist Euplotes crassus, and provides an effective mechanism for reducing populations of potential competitors through its cytotoxic properties. However, intracellular signaling mechanisms and their functional correlates mediating the ecological role of euplotin C are largely unknown. We report here that, in E. vannus (an Euplotes morphospecies which does not produce euplotin C and shares with E. crasssus the same interstitial habitat), euplotin C rapidly increases the intracellular concentration of both Ca2+ and Na+, suggesting a generalized effect of this metabolite on cation transport systems. In addition, euplotin C does not induce oxidative stress, but modulates the electrical properties of E. vannus through an increase of the amplitude of graded action potentials. These events parallel the disassembling of the ciliary structures, the inhibition of cell motility, the occurrence of aberrant cytoplasmic vacuoles, and the rapid inhibition of phagocytic activity. Euplotin C also increases lysosomal pH and decreases lysosomal membrane stability of E. vannus. These results suggest that euplotin C exerts a marked disruption of those homeostatic mechanisms whose efficiency represents the essential prerequisite to face the challenges of the interstitial environmental. | it |
dc.language.iso | en | it |
dc.publisher | Wiley-Blackwell | it |
dc.subject | Action potentials | it |
dc.subject | Cation homeostasis | it |
dc.subject | Ciliated protists | it |
dc.subject | Lysosomes | it |
dc.subject | Marine microorganisms | it |
dc.subject | Oxidative stress | it |
dc.subject | Phagocytosis | it |
dc.subject | Sesquiterpenoids | it |
dc.title | Action Mechanisms of the Secondary Metabolite Euplotin C: Signaling and Functional Role in Euplotes | it |
dc.type | Article | it |
dc.identifier.doi | 10.1111/j.1550-7408.2008.00335.x | it |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | DISA - Archivio della produzione scientifica |
Files in This Item:
File | Description | Size | Format | |
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Trielli et al J Euk Microbiol 2008 1.pdf | 41.55 kB | Adobe PDF | View/Open |
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