Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1448
Title: Adenylyl cyclase/cAMP system involvement in the antiangiogenic effect of somatostatin in the retina. Results from transgenic mice.
Authors: Ristori, Chiara
Ferretti, Maria Enrica
Pavan, Barbara
Cervellati, Franco
Casini, Giovanni
Catalani, Elisabetta
Dal Monte, Massimo
Biondi, Carla
Keywords: Somatostatin;Mouse retina
Issue Date: 2008
Publisher: Springer Verlag
Source: Ristori, C. et al. 2008. Adenylyl cyclase/cAMP system involvement in the antiangiogenic effect of somatostatin in the retina. Results from transgenic mice. "Neurochemical Research" 33 (7): 1247-1255
Abstract: 
Neoangiogenesis is a response to retinal hypoxia that is inhibited by somatostatin (SRIF) through its subtype 2 receptor (sst2). Using a mouse model of hypoxia-induced retinopathy, we investigated the possibility that inhibition of adenylyl cyclase (AC) is involved in SRIF anti-angiogenic actions. Hypoxia increased AC responsiveness in wild type (WT) retinas and in retinas lacking sst2, but not in sst2-overexpressing retinas. Hypoxia also altered AC isoform expression, but with different patterns depending on sst2 expression level. Among the nine AC isoforms, AC VII isoform mRNA and protein resulted the most affected. Indeed, in hypoxia AC VII expression was significantly enhanced in WT retinas and it was further increased in sst2-lacking retinas, but not in retinas overexpressing sst2. These data suggest an involvement of AC/cAMP in mediating both hypoxia-evoked retinal neoangiogenesis and SRIF protective actions. The AC VII isoform is a candidate to a main role in these mechanisms.
Description: 
L'articolo è disponibile sul sito dell'editore http://www.springerlink.com/
URI: http://hdl.handle.net/2067/1448
ISSN: 0364-3190
DOI: 10.1007/s11064-007-9576-6
Appears in Collections:DISA - Archivio della produzione scientifica

Files in This Item:
File Description SizeFormat
Ristori et al 2008.pdf459.68 kBAdobe PDFView/Open
Show full item record

Page view(s)

1
Last Week
0
Last month
0
checked on Dec 2, 2020

Download(s)

7
checked on Dec 2, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.