Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2067/1439
Titolo: Localization patterns of fibroblast growth factor 1 and its receptors FGFR1 and FGFR2 in postnatal mouse retina
Autori: Catalani, Elisabetta
Tomassini, Silvia
Bosco, Luigi
Casini, Giovanni
Parole chiave: Development;Retinal ganglion cells;Amacrine cells;Horizontal cells;Müller cells
Data pubblicazione: 2009
Editore: Springer Verlag
Fonte: Ctalani, E. et al. 2009. Localization patterns of fibroblast growth factor 1 and its receptors FGFR1 and FGFR2 in postnatal mouse retina. "Cell and Tissue Research" 336(3): 423-438
Abstract: 
Fibroblast growth factors (FGFs) exert basic functions both during embryonic development and in the adult. In mammalian retinas, expression of FGFs and their receptors has been reported, however information on the organization of the FGF system is still incomplete. Here, we report detailed double label immunohistochemical investigations of the localization patterns of FGF1 and of its receptors FGFR1 and FGFR2 in adult and in early postnatal mouse retinas. In adult retinas, FGF1 is localized to ganglion cells, horizontal cells and photoreceptor inner and outer segments. FGFR1 is in ganglion cells and in Müller cells, while FGFR2 is primarily localized to ganglion cells and to the nuclei of Müller cells, in addition to glycine containing amacrine cells. During postnatal development, the patterns of FGF1, FGFR1 or FGFR2 immunostainings are similar to those in the adult, but transient FGF1 expressing cells are detected in the proximal inl before eye opening. These patterns are consistent with an important involvement of FGF1, FGFR1 and FGFR2 in ganglion cell maturation (during development) and survival (in the adult). In addition, FGF1 may affect amacrine cell development, while Müller cells appear to receive important regulation from both FGFR1 and FGFR2 throughout postnatal life. Finally, in immature retinas, large numbers of amacrine cells, including calbindin and glycine containing amacrine cells, display both FGF1 and FGFR2 immunoreactivities in their nuclei, suggesting an action of FGF1 on FGFR2 receptors during a restricted period of postnatal development for the maturation of these amacrine cells.
Acknowledgments: 
L'articolo è disponibile sul sito dell'editore http://www.springerlink.com
URI: http://hdl.handle.net/2067/1439
ISSN: 0302-766X
DOI: 10.1007/s00441-009-0787-9
È visualizzato nelle collezioni:DISA - Archivio della produzione scientifica

File in questo documento:
File Descrizione DimensioniFormato
Catalani et al 2009.pdf4 MBAdobe PDFVisualizza/apri
Visualizza tutti i metadati del documento

SCOPUSTM
Citations 5

19
Last Week
0
Last month
controllato il 2-lug-2022

Page view(s)

43
Last Week
18
Last month
10
controllato il 5-lug-2022

Download(s)

91
controllato il 5-lug-2022

Google ScholarTM

Check

Altmetric


Tutti i documenti nella community "Unitus Open Access" sono pubblicati ad accesso aperto.
Tutti i documenti nella community Prodotti della Ricerca" sono ad accesso riservato salvo diversa indicazione per alcuni documenti specifici