Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/143
Title: Effects of nonesterified fatty acids on lymphocyte functions in dairy heifers
Authors: Lacetera, Nicola
Scalia, Daniela
Franci, Ombretta
Bernabucci, Umberto
Ronchi, Bruno
Nardone, Alessandro
Keywords: Heifer;Nonesterified fatty acid;Lymphocyte function
Issue Date: 2004
Publisher: American Dairy Science Association
Source: Lacetera, N. et al. 2004. Effects of nonesterified fatty acids on lymphocyte functions in dairy heifers. "Journal of Dairy Science", 87 (4): 1012-1014
Abstract: 
This in vitro study was performed to assess the effects of various concentrations of nonesterified fatty acids (NEFA) on lymphocyte function of heifers. Nine Holstein heifers were studied. Peripheral blood mononuclear cells were incubated with various concentrations of NEFA (0, 0.0625, 0.125, 0.25, 0.5, 1, and 2 mmol/L).
The mixture of NEFA was represented by C16:0 (30%), C16:1 (5%), C18:0 (15%), C18:1 (45%), and C18:2 (5%). The DNA synthesis was diminished at concentrations of NEFA of 2, 1, and 0.5 mmol/L. The IgM secretion was inhibited at concentrations of NEFA of 2, 1, 0.5, and 0.25 mmol/L. Secretion of IFN-γ was depressed at concentrations of NEFA of 2, 1, 0.5, 0.25, and 0.125 mmol/L. Increases of plasma NEFA might contribute to explain the higher incidence of infections observed in cows suffering from energy deficit.
URI: http://hdl.handle.net/2067/143
ISSN: Print ISSN: 0022-0302 Online ISSN: 1525-3198
Appears in Collections:DiPA - Archivio della produzione scientifica

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