Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1345
DC FieldValueLanguage
dc.contributor.authorLorenti Garcia, Claudia-
dc.contributor.authorFilippi, Silvia-
dc.contributor.authorMosesso, Pasquale-
dc.contributor.authorMenotti Calvani, R.-
dc.contributor.authorNicolai, Raffaella-
dc.contributor.authorMosconi, Luigi-
dc.contributor.authorPalitti, Fabrizio-
dc.date.accessioned2011-03-17T18:36:47Z-
dc.date.available2011-03-17T18:36:47Z-
dc.date.issued2006-
dc.identifier.citationLorenti Garcia, C. et al. 2006. The protective effect of L-Carnitine in peripheral blood human lymphocytes exposed to oxidative agents. "Mutagenesis" 21(1): 21-27en
dc.identifier.issn1383-5718-
dc.identifier.urihttp://hdl.handle.net/2067/1345-
dc.descriptionL'articolo é disponibile sul sito dell'editore: http://www.oxfordjournals.orgit
dc.description.abstractLiterature data indicate l-carnitine (LC), a trans-mitochondrial carrier of acetyl and long chain groups, as an agent possessing protective effects against oxidative stress in mammalian cells. However, the major factor involved in the protective mechanism is not known. The protection activity exerted by this agent against reactive oxygen species induced by hydrogen peroxide (H2O2) and t-butylhydroperoxide (t-butyl-OOH) treatment in isolated human peripheral blood lymphocytes (PBLs) has been studied. Human lymphocytes cells were isolated and pre-incubated with 5 mM lc before H2O2 (100 µM) and t-butyl-OOH (400 µM) treatment. The protective effect of lc on treated PBLs was measured by single cell gel electrophoresis and the analysis of chromosomal aberrations. Results show that lc treated cells exhibited a significant decrease in the number of oxidative induced single-strand breaks and chromosomal aberrations.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.titleThe protective effect of L-Carnitine in peripheral blood human lymphocytes exposed to oxidative agentsen
dc.typeArticleen
dc.identifier.doi10.1093/mutage/gei065-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.cerifentitytypePublications-
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