Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1341
Title: Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities
Authors: Fiani, Cinzia
Belfiore, Maria Cristina
Gualandi, Giampiero
Penna, Sabrina
Mosesso, Pasquale
Issue Date: 2005
Publisher: Elsevier
Source: Saladino, R. et al. 2005. Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities. "Bioorganic & Medicinal Chemistry" 13: 5949–5960
Abstract: 
A novel and efficient procedure to prepare highly oxidised aryltetralin lignans, such as isopodophyllotoxone and (-)-aristologone
derivatives, by oxidation of podophyllotoxin and galbulin with methylrhenium trioxide (MTO) and novel MTO heterogeneous
catalysts is reported. It is noteworthy that in the case of isopodophyllotoxone derivatives the functionalisation of the
C-4 position of the C-ring and the ring-opening of the D-lactone moiety increased the activity against topoisomerase II while causing
the undesired inhibition of tubulin polymerisation to disappear. The novel (-)-aristologone derivatives showed apoptogenic
activity against resistant human lymphoma cell lines.
Description: 
L'articolo è disponibile sul sito dell'editore: http://www.sciencedirect.com
URI: http://hdl.handle.net/2067/1341
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2005.07.017
Appears in Collections:DABAC - Archivio della produzione scientifica

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