Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1332
Title: Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells
Authors: Bernabucci, Umberto
Colavecchia, Luciana
Danieli, Pier Paolo
Basiricò, Loredana
Lacetera, Nicola
Nardone, Alessandro
Ronchi, Bruno
Keywords: Aflatoxin B1;Aflatossina B1;Fumonisin B1;Fumonisina B1;Oxidative stress;Stress Ossidativo;PBMC;Linfociti;Dairy cattle;Bovini da latte
Issue Date: 2011
Publisher: Elsevier
Source: Bernabucci, U. et al. 2011. Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells. "Toxicology in vitro" 25: 684-691
Abstract: 
This in vitro study was focused on the effect of two widely occurring mycotoxins, aflatoxin B1 (AFB1) and fumonisin B1 (FB1), on the oxidative status of bovine peripheral blood mononuclear cells (PBMC) incubated for 2 and 7 days at different levels of AFB1 (0, 5 and 20 lg/ml) and FB1 (0, 35 and 70 lg/ml). Results of the present study demonstrate that, even though by different mechanisms, AFB1 and FB1 may induce cytotoxicity through an impairment of the oxidative status of PBMC.

Lo studio in vitro ha lo scopo di verificare l’effetto della esposizione ad aflatossina B1 (AFB1) e fumonisina B1 (FB1) di sullo stato ossidativo di linfociti bovini incubati per 2 o 7 giorni con differenti concentrazioni di tossine (AFB1: 0, 5 and 20 mcg/ml and FB1: 0, 35 and 70 mcg/ml).
I risultati del presente studio hanno dimostrato, anche se attraverso meccanismi differenti, che entrambe le tossine inducono citotossicità attraverso il peggioramento dello stato ossidativo.
Description: 
L'articolo è disponibile sul sito dell'editore: http://www.sciencedirect.com/science/journal/08872333
URI: http://hdl.handle.net/2067/1332
ISSN: 0887-2333
DOI: 10.1016/j.tiv.2011.01.009
Appears in Collections:DiPA - Archivio della produzione scientifica

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