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  5. Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells

Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells

Author(s)
Bernabucci, Umberto
Colavecchia, Luciana
Danieli, Pier Paolo
Basiricò, Loredana  
Lacetera, Nicola
more
Date Issued
2011
Type
Article
DOI
10.1016/j.tiv.2011.01.009
Abstract
This in vitro study was focused on the effect of two widely occurring mycotoxins, aflatoxin B1 (AFB1) and fumonisin B1 (FB1), on the oxidative status of bovine peripheral blood mononuclear cells (PBMC) incubated for 2 and 7 days at different levels of AFB1 (0, 5 and 20 lg/ml) and FB1 (0, 35 and 70 lg/ml). Results of the present study demonstrate that, even though by different mechanisms, AFB1 and FB1 may induce cytotoxicity through an impairment of the oxidative status of PBMC. Lo studio in vitro ha lo scopo di verificare l’effetto della esposizione ad aflatossina B1 (AFB1) e fumonisina B1 (FB1) di sullo stato ossidativo di linfociti bovini incubati per 2 o 7 giorni con differenti concentrazioni di tossine (AFB1: 0, 5 and 20 mcg/ml and FB1: 0, 35 and 70 mcg/ml). I risultati del presente studio hanno dimostrato, anche se attraverso meccanismi differenti, che entrambe le tossine inducono citotossicità attraverso il peggioramento dello stato ossidativo.
Additional information
L'articolo è disponibile sul sito dell'editore: http://www.sciencedirect.com/science/journal/08872333
Citation
Bernabucci, U. et al. 2011. Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells. "Toxicology in vitro" 25: 684-691
Subjects

Aflatoxin B1

Aflatossina B1

Fumonisin B1

Fumonisina B1

Oxidative stress

Stress Ossidativo

PBMC

Linfociti

Dairy cattle

Bovini da latte

Handle
http://hdl.handle.net/2067/1332
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