Mapping of the full length and the truncated interleukin-18 receptor alpha transcripts in the mouse brain
Author(s)
Date Issued
2009
Type
Article
Abstract
The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Rα\β. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Rα transcripts, a full length and an isoform lacking the intracellular domain
hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.
Additional information
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Citation
Alboni, S. et al. 2009. Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain. "Journal of Neuroimmunology" 214(1-2): 43-54
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