Influence of DMSO on Carbon K ultrasoft X-rays induced chromosome aberrations in V79 Chinese hamster cells
Author(s)
Natarajan, Adayapalam T.
Palitti, Fabrizio
Hill, Mark A.
Stevens, David L.
Ahnström, Gunnar
Date Issued
2010
Type
Article
Abstract
Ultrasoft X-rays have been shown to be very efficient in inducing chromosomal aberrations in mammalian cells. The present study was aimed to evaluate the modifying effects of DMSO (a potent scavenger of free radicals) on the frequencies of chromosome aberrations induced by soft X-rays. Confluent held G1 Chinese hamster cells (V79) were irradiated with Carbon K ultrasoft X-rays in the presence and absence of 1 M DMSO and frequencies of chromosome aberrations in the first division cells were determined. DMSO reduced the frequencies of exchange types of aberrations (dicentrics and centric rings) by a factor of 2.1–3.5. The results indicate that free radicals induced by ultrasoft X-rays contribute to a great extent to the induction of chromosome aberrations. The possible implications of these results in interpreting the mechanisms involved in the high efficiency of ultrasoft X-rays in the induction of chromosome aberrations are discussed.
Additional information
L'aricolo è disponibile sul sito dell'editore: http://www.sciencedirect.com
Citation
Natarajan, A.T. et al. 2010. Influence of DMSO on Carbon K ultrasoft X-rays induced chromosome aberrations in V79 Chinese hamster cells. "Mutation Research" 691(1-2): 23-26
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DMSOfinal.pdf
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Checksum (MD5)
843517a2c2ac77450f6c967e8cfe48c9
Sponsor(s)
University of Tuscia, Viterbo, Italy and The Swedish Radiation Safety Authority, EU-FIGH-CT 1999-00012