The Spike Mutants Website: A Worldwide Used Resource against SARS-CoV-2
Author(s)
Romeo, Isabella
Guarnetti Prandi, Ingrid
Giombini, Emanuela
Gruber, Cesare Ernesto Maria
Date Issued
2022
Type
article
Volume
23
Issue
21
Abstract
A large number of SARS-CoV-2 mutations in a short period of time has driven scientific research related to vaccines, new drugs, and antibodies to combat the new variants of the virus. Herein, we present a web portal containing the structural information, the tridimensional coordinates, and the molecular dynamics trajectories of the SARS-CoV-2 spike protein and its main variants. The Spike Mutants website can serve as a rapid online tool for investigating the impact of novel mutations on virus fitness. Taking into account the high variability of SARS-CoV-2, this application can help the scientific community when prioritizing molecules for experimental assays, thus, accelerating the identification of promising drug candidates for COVID-19 treatment. Below we describe the main features of the platform and illustrate the possible applications for speeding up the drug discovery process and hypothesize new effective strategies to overcome the recurrent mutations in SARS-CoV-2 genome.
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2022_10_IJMS_Romeo.pdf
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