Trematocine-derived antimicrobial peptides from the Antarctic fish Trematomus bernacchaii: potent antibacterial agents against ESKAPE pathogens
Author(s)
Squitieri, Damiano
Graziano, Monica Mollica
Cacaci, Margherita
Date Issued
2024
Type
article
Volume
15
Start Page
1447301
Journal
Abstract
This study investigated the interaction with membrane mimetic systems (LUVs), bacterial membranes, the CD spectra, and the bactericidal activity of two designed trematocine mutants, named Trem-HK and Trem-HSK. Mutants were constructed from the scaffold of Trematocine (Trem), a natural 22-amino acid AMP from the Antarctic fish Trematomus bernacchii, aiming to increase their positive charge.
Project(s)
Project Title: Fish-inspired antimicrobial peptide delivered by specific nanosystems to fight ESKAPE bacteria: a powerful weapon against antibiotic resistance (code 2022FKLKSY)—CUP J53D23001090006