Palladium-catalyzed synthesis of 6-aryl dopamine derivatives
Author(s)
Date Issued
2024
Type
article
Volume
14
Issue
7
Start Page
401
End Page
415
Journal
Abstract
Dopamine is a key neurotransmitter involved in a series of biologically relevant processes
and its derivatives have sparked significant interest as intriguing synthetic targets. This class of
compounds is indeed not only considerable for the potential biological activities but is also promising
for diverse applications in material science. In light of this, our research was focused on the
synthesis of 6-aryldopamine derivatives starting from 4-(2-aminoethyl)phenol through a sequential protocol, whose main steps are hydroxylation, halogenation, and Suzuki cross-coupling. Our method demonstrated versatility, efficiency, and compatibility with various functional groups, including aldehydes, ketones, esters, ethers, and fluorine.