Cytogenetic evaluation of extractable agents from airborne particulate matter generated in the city of Catania (Italy)
Author(s)
Date Issued
2004
Type
Article
Abstract
In order to document cytogenetic damage associated with air pollution and, possibly, with health effects in the city of
Catania, Sicily (Italy), we analyzed the induction of chromosomal aberrations by extractable agents from airborne particulate
matter in a Chinese hamster epithelial liver (CHEL) cells. These cells retain their metabolic competence to activate different
classes of promutagens/procarcinogens into biologically active metabolites. Airborne particulate matter was obtained from
two stationary samplers (stations I and II) in two areas endowed by an elevated car transit in the centre of Catania. The results
obtained clearly indicated that airborne particulate matter from both stations I and II proved to be clastogens in CHEL cells
but not in Chinese hamster ovary (CHO) cells without metabolic activation, indicating that airborne particulate mixtures need
to be metabolically converted before exerting their genotoxic potential.
On the basis of these results we can assert that the test system employed to identify the cytogenetic potential of airborne
particulate matter is useful and profitable for environmental control, and helpful to plan specific actions aimed at reducing the
hazards derived from exposure to polluted air.
Additional information
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Citation
Motta, S. et al. 2004. Cytogenetic evaluation of extractable agents from airborne particulate matter generated in the city of Catania (Italy). "Mutation Research. Genetic Toxicology and Environmental Mutagenesis".
561(1-2): 45-52.
561(1-2): 45-52.
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