Comparative transcriptomics reveals different profiles between diflubenzuron-resistant and -susceptible phenotypes of the mosquito Culex pipiens

Valentina, Mastrantonio; Franco, Liberati; Castrignanò, Tiziana; Valentina, Lucchesi; Sandra, Urbanelli; Romeo, Bellini; John, Vontas; Daniele, Porretta

doi:10.1002/ps.8710

Comparative transcriptomics reveals different profiles between diflubenzuron-resistant and -susceptible phenotypes of the mosquito Culex pipiens

Author(s)

Valentina, Mastrantonio

Franco, Liberati

Castrignanò, Tiziana

Valentina, Lucchesi

Sandra, Urbanelli

more

Date Issued

2025

Type

article

Volume

81

Issue

6

Start Page

3370

End Page

3377

DOI

10.1002/ps.8710

Journal or Series

PEST MANAGEMENT SCIENCE

Abstract

Chitin-synthesis inhibitors (CSIs) represent a major tool in vector control. The intensive use of these compounds has led to the evolution of resistance against several CSIs, including diflubenzuron (DFB). DFB resistance has been associated to a target-site mechanism; however, studies investigating the gene expression profile of resistant phenotypes are limited, preventing a full understanding of DFB resistance. Here, we analyzed the constitutive gene expression of susceptible and DFB-resistant individuals of the mosquito Culex pipiens, a major disease vector in temperate areas.

Handle

http://hdl.handle.net/2067/53796