Relationship between DNA Repair and Formation of Sister Chromatid Exchanges and Chromatid Aberrations under the Influence of Poly(ADP-Ribose) Polymerase Inhibition by 3-Aminobenzamide
Author(s)
Filippi, Silvia
Palitti, Fabrizio
Martínez-López, Wilner
Natarajan, Adayapalam T.
Date Issued
2010
Type
Article
Abstract
The mechanisms of formation of sister chromatid exchanges (SCEs) and chromosome aberrations following inhibition of poly(ADP-ribose) polymerase by 3-aminobenzamide were studied in Chinese hamster ovary cell lines deficient in different repair pathways. The results confirm earlier findings that (a) the 'spontaneous' SCEs are formed due to the incorporated BrdU in the DNA, (b) 'spontaneous' and induced SCEs originate from different mechanisms, and (c) SCEs and chromatid exchanges are formed by different pathways.
Additional information
L'articolo é disponibile sul sito dell'editore: http://www.karger.com
Citation
Filippi, S. et al. 2010. Relationship between DNA Repair and Formation of Sister Chromatid Exchanges and Chromatid Aberrations under the Influence of Poly(ADP-Ribose) Polymerase Inhibition by 3-Aminobenzamide. "Cytogenetic and Genome Research" 128(1-3): 118-23
Subjects
File(s)![Thumbnail Image]()
Name
3Ab_Repair.pdf
Size
54.55 KB
Format
Adobe PDF
Checksum (MD5)
5e9423d22be5cddd6334c3618acb7e03
Sponsor(s)
University of Tuscia