Interleukin 18 in the CNS
Author(s)
Alboni, Silvia
Cervia, Davide
Sugama, Shuei
Conti, Bruno
Date Issued
2010
Type
Article
Abstract
Interleukin (IL)-18 is cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behaviour. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.
Additional information
L'articolo รจ disponibile sul sito dell'editore http://www.biomedcentral.com/
Citation
Alboni, S. et al. 2010. Interleukin 18 in the CNS. "Journal of Neuroinflammation" 7:9
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