Meteorite-catalyzed intermolecular trans-glycosylation produces nucleosides under proton beam irradiation
Author(s)
Date Issued
2021
Type
article
Volume
11
Issue
31
Start Page
19258
End Page
19264
Journal
Abstract
Di-glycosylated adenines act as glycosyl donors in the intermoleculartrans-glycosylation of pyrimidine nucleobases under proton beam irradiation conditions. Formamide and chondrite meteorite NWA 1465 increased the yield and the selectivity of the reaction. The glycosyl transfer process was highly regioselective in yielding canonicalN1-pyrimidine nucleosides, the natural β-anomers prevailing in the presence of formamide and NWA 1465. These data highlight the possible role of intermoleculartrans-glycosylation in the prebiotic formation of purine and pyrimidine nucleosides, avoiding the occurrence of independent synthetic pathways.