How stereochemistry of lipid components can affect lipid organization and the route of liposome internalization into cells
Author(s)
Date Issued
2021
Type
article
Volume
13
Issue
27
Start Page
11976-11993
End Page
11993
Journal
Abstract
Though liposome-based drugs are in clinical use, the mechanism of cell internalization of liposomes is yet an object of controversy. The present experimental investigation, carried out on human glioblastoma cells, indicated different internalization routes for two diastereomeric liposomes. Molecular dynamics simulations of the lipid bilayers of the two formulations indicated that the different stereochemistry of a lipid component controls some parameters such as area per lipid molecule and fluidity of lipid membranes, surface potential and water organization at the lipid/water interface, all of which affect the interaction with biomolecules and cell components.