Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine n-oxides with anti-influenza a virus activity
Author(s)
Date Issued
2021
Type
article
Volume
22
Issue
3
Start Page
1
End Page
14
Abstract
Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.