Expression and oxidative modifications of plasma proteins in autism spectrum disorders
Author(s)
Date Issued
2016
Type
article
ISSN
18628354
Abstract
Purpose: A role for inflammation and oxidative stress is reported in autism spectrum disorders
(ASDs). Here, we tested possible changes in expression and/or oxidative status for plasma
proteins in subjects with ASDs.
Experimental design: To evaluate protein expression and protein adducts of lipid peroxidationderived aldehyde, analysis of plasma proteins was performed in 30 subjects with ASDs and
compared with 30 healthy controls with typical development, using a proteomic approach.
Results: Significant changes were evidenced for a total of 12 proteins. Of these, ten were identified as proteins involved in the acute inflammatory response including alpha-2-macroglobulin,
alpha-1-antitrypsin, haptoglobin, fibrinogen, serum transferrin, prealbumin, apolipoprotein A-I
apolipoprotein A-IV, apolipoprotein J, and serum albumin. In addition, significant changes occurred for two immunoglobulins alpha and gamma chains.
Conclusions and clinical relevance: Our present data indicate that an inflammatory response,
coupled with increased lipid peroxidation, is present in subjects with ASDs. This information
can provide new insight into the identification of potential plasma protein biomarkers in autism.
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Checksum (MD5)
495e7fbb7ecdca6ce3e96ff9924c6e67
Conference(s)
PROTEOMICS. CLINICAL APPLICATIONS