Transport of cationic liposomes in a human blood brain barrier model:
Role of the stereochemistry of the gemini amphiphile on liposome
biological features

Buonocore, Francesco; Beatrice Simonis; D. Vignone; O. Gonzalez Paz; E. Donati; M.L. Falchetti; C. Bombelli; A. Cellucci; G. Auciello; I. Fini; L. Galantini; R.Z.R. Syeda; M. Mazzonna; M.P. Mongiardi; F. Ceccacci; A. Di Marco; G. Mancini

doi:https://doi.org/10.1016/j.jcis.2022.07.025

Transport of cationic liposomes in a human blood brain barrier model: Role of the stereochemistry of the gemini amphiphile on liposome biological features

Author(s)

Buonocore, Francesco

Beatrice Simonis

D. Vignone

O. Gonzalez Paz

E. Donati

more

Date Issued

2022

Type

article

Volume

627

Start Page

283

End Page

298

DOI

https://doi.org/10.1016/j.jcis.2022.07.025

Journal

JOURNAL OF COLLOID AND INTERFACE SCIENCE

Abstract

Hypothesis: The positive charge on liposome surface is known to promote the crossing of the Blood brain barrier (BBB). However, when diastereomeric cationic gemini amphiphiles are among lipid membrane components, also the stereochemistry may affect the permeability of the vesicle across the BBB. Experiments: Liposomes featuring cationic diasteromeric gemini amphiphiles were formulated, characterized, and their interaction with cell culture models of BBB investigated.

Handle

http://hdl.handle.net/2067/48325

File(s)

Name

1-s2.0-S002197972201195XLiposomeBrain.pdf

Size

5.16 MB

Format

Adobe PDF

Checksum (MD5)

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