Massive screening of copy number population-scale variation in Bos taurus genome

Cicconardi, Francesco; Chillemi, Giovanni; Tramontano, Anna; Marchitelli, Cinzia; Valentini, Alessio; Ajmone-Marsan, Paolo; Nardone, Alessandro

doi:10.1186/1471-2164-14-124

Massive screening of copy number population-scale variation in Bos taurus genome

Author(s)

Cicconardi, Francesco

Chillemi, Giovanni

Tramontano, Anna

Marchitelli, Cinzia

Valentini, Alessio

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Date Issued

2013

Type

article

Volume

14

Issue

1

Start Page

124

DOI

10.1186/1471-2164-14-124

Journal

BMC GENOMICS

Abstract

Copy number variations (CNVs) represent a significant source of genomic structural variation. Their length ranges from approximately one hundred to millions of base pair. Genome-wide screenings have clarified that CNVs are a ubiquitous phenomenon affecting essentially the whole genome. Although Bos taurus is one of the most important domestic animal species worldwide and one of the most studied ruminant models for metabolism, reproduction, and disease, relatively few studies have investigated CNVs in cattle and little is known about how CNVs contribute to normal phenotypic variation and to disease susceptibility in this species, compared to humans and other model organisms.

Handle

http://hdl.handle.net/2067/47380