Hydroxytyrosol-derived compounds: a basis for the creation of new pharmacological agents for cancer prevention and therapy
Author(s)
Date Issued
2015
Type
article
Volume
58
Issue
58
Start Page
9089
End Page
9107
ISSN
222623
15204804
Journal
Abstract
Hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol, HTyr] is a phenolic compound found in olive leaves and fruits and extra-virgin olive oil, which has well-known strong antioxidant and radical-scavenging properties. Recently, it has received particular attention for its antiproliferative and apoptotic activities and its anti-inflammatory properties. During the past few years, more efforts have been focused on synthesizing HTyr-derived compounds with enhanced biological activities for their potential use in different chronic degenerative diseases. In this paper, we report a dissertation on the current knowledge of selected synthetic HTyr derivatives and analogues and their potential use in cancer prevention and therapy, which are related to their antioxidant, antiproliferative/apoptotic, and anti-inflammatory properties. On the basis of the perspective of using HTyr-derived compounds as anticancer agents, we have taken into account only studies that were performed in experimental cell-based models.
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JMC 2015_submitted.pdf
Size
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Format
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Checksum (MD5)
f6a4c192aa0f73f81a836507fcba645b
Conference(s)
JOURNAL OF MEDICINAL CHEMISTRY