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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/2068

Title: Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells
Authors: Belfiore, Maria Cristina
Natoni, Alessandro
Barzellotti, Roberta
Merendino, Nicolò
Pessina, Gloria
Gualandi, Giampiero
Keywords: Apoptosis
Issue Date: 2007
Publisher: Elsevier
Citation: Belfiore, M. C. et al. 2007. Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells. "Cancer Letters" 254 (2): 236-243
Abstract: Epstein–Barr Virus (EBV) is involved in the progression of lymphomas through still unknown mechanism involving increased resistance to induced apoptosis. We show here that in a set of apoptosis-resistant EBV-converted Burkitt’s lymphoma clones, 5- and 12-lipoxygenases (LOXs) are over-expressed. Further investigations on 5-LOX showed that resistance to apoptosis increases parallely with the expression of 5-lipoxygenase (5-LOX). Inhibitors of 5-LOX: (a) decrease peroxides level, indicating that t
Description: L'articolo è disponibile sul sito dell'editore http://www.sciencedirect.com
DOI: 10.1016/j.canlet.2007.03.010
URI: http://hdl.handle.net/2067/2068
ISSN: 0304-3835
Appears in Collections:DECOS - Archivio della produzione scientifica

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