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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1843

Title: Recombinant clotting factor VIII concentrates: Heterogeneity and high-purity evaluation
Authors: D'Amici, Gian Maria
Timperio, Anna Maria
Gevi, Federica
Grazzini, Giuliano
Zolla, Lello
Keywords: 2-DE
Hemophilia A
Proteomics
Recombinant factor VIII
Issue Date: 2010
Publisher: Wiley-Blackwell
Citation: D'Amici, G.M. et al. 2010. Recombinant clotting factor VIII concentrates: Heterogeneity and high-purity evaluation. "Electrophoresis" 31(16): 2730-2739
Abstract: Factor VIII is an important glycoprotein involved in hemostasis. Insertion of expression vectors containing either the full-length cDNA sequence of human factor VIII (FLrFVIII) or B-domain deleted (BDDrFVIII) into mammalian cell lines results in the production of recombinant factor VIII (rFVIII) for therapeutic usage. Three commercially available rFVIII concentrates (Advates, Helixate NexGens and Refactos), either FLrFVIII or BDDrFVIII, were investigated by 1- and 2-DE and MS. The objective
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Description: L'artcoo è disponibile sul sito dell'editore http://onlinelibrary.wiley.com/
DOI: 10.1002/elps.201000216
URI: http://hdl.handle.net/2067/1843
ISSN: 0173-0835
Appears in Collections:DISA - Archivio della produzione scientifica

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