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|Title: ||Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques.|
|Authors: ||Mosesso, Pasquale|
Van Der Berg, Marco A.
Vermeulen, Sandra S.
Natarajan, Adayapalam T.
|Issue Date: ||1998|
|Publisher: ||Oxford University Press|
|Citation: ||Mosesso, P. et al. 1998. Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques. "Mutagenesis" 13(1): 39-43|
|Abstract: ||Frequencies of symmetrical and asymmetrical exchange aberrations induced by two inhibitors of topoisomerase II, namely, 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA) and etoposide (VP16), were estimated in human peripheral blood lymphocytes. The aberrations were scored using conventional Giemsa staining and fluorescence in situ hybridization (FISH) techniques, using chromosome-specific DNA libraries. Stable aberrations (translocations) were detected using two cocktails of DNA librarie|
|Description: ||L'articolo è disponibile sul sito dell'editore: http://www.oxfordjournals.org|
|Appears in Collections:||DABAC - Archivio della produzione scientifica|
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