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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1721

Title: Distribution of camptothecin-induced breakpoints in Chinese hamster cells treated in late S and G2 phases of the cell cycle.
Authors: Bassi, Loredana
Palitti, Fabrizio
Mosesso, Pasquale
Natarajan, Adayapalam T.
Issue Date: 1998
Publisher: Oxford University Press
Citation: Bassi, L. et al. 1998. Distribution of camptothecin-induced breakpoints in Chinese hamster cells treated in late S and G2 phases of the cell cycle. "Mutagenesis" 13: 257-261
Abstract: The distribution of camptothecin (CPT)-induced break points in late S or G2 phase of the cell cycle observed in Chinese hamster chromosomes was analysed in 400 metaphases. Contrary to expectation, they were not localized in the heterochromatic regions, suggesting that these chromatid-type aberrations arise by a mechanism which does not involve collision of the CPT-trapped 'cleavable complex' with the replication fork. Since many break points mapped more frequently to light bands (DAPI negative)
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Description: L'articolo è disponibile sul sito dell'editore: http://www.oxfordjournals.org
URI: http://hdl.handle.net/2067/1721
ISSN: 0267-8357
Appears in Collections:DABAC - Archivio della produzione scientifica

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