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http://hdl.handle.net/2067/1720
Title: | Chromosome radiosensitivity in human G2 lymphocytes and cell cycle progression | Authors: | Palitti, Fabrizio Pichierri, Pietro Franchitto, Annapaola Proietti De Santis, Luca Mosesso, Pasquale |
Issue Date: | 1999 | Publisher: | Informa Healthcare | Source: | Palitti, F. et al. 1999. Chromosome radiosensitivity in human G2 lymphocytes and cell cycle progression. "International Journal of Radiation Biology" 75(5): 621-627 | Abstract: | PURPOSE: To investigate the possibility that the differential G2-phase radiosensitivity of human peripheral blood lymphocytes, found in normal individuals using the 'G2-phase chromosome radiosensitivity assay', could be attributed to heterogeneity in cellular progression to mitosis rather than differences in radiosensitivity. MATERIALS AND METHODS: Human peripheral blood lymphocytes, from four different donors, were exposed to 50 cGy X-rays and sampled at different times. The progression of cells into mitosis was monitored by 5-bromo 2'-deoxyuridine (BrdUrd) incorporation. RESULTS: The heterogeneous G2-phase chromosome radiosensitivity among different donors was abolished when homogeneous G2-phase cell populations were scored; they contained similar frequencies of cells in early or late G2-phase. CONCLUSIONS: The heterogeneous G2-phase chromosome radiosensitivity, usually found in different normal donors, is caused by the analysis of different cell populations rather than reflecting intrinsic differences in radiosensitivity |
Description: | L'articolo è disponibile sul sito dell'editore: http://informahealthcare.com |
URI: | http://hdl.handle.net/2067/1720 | ISSN: | 0955-3002 |
Appears in Collections: | DABAC - Archivio della produzione scientifica |
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