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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1719

Title: The involvement of chromatin condensation in campthotecin-induced chromosome breaks in G0 human lymphocytes
Authors: Mosesso, Pasquale
Fonti, Enrica
Bassi, Loredana
Lorenti Garcia, Claudia
Palitti, Fabrizio
Keywords: Premature chromosome condensation
PCC
Dna single strand breaks
Condensazione prematura dei cromosomi
PCC
Rotture dl DNA a singolo filamento
Issue Date: 1999
Publisher: Oxford University Press
Citation: Mosesso, P. et al. 1999. The involvement of chromatin condensation in campthotecin-induced chromosome breaks in G0 human lymphocytes. "Mutagenesis" 14(1): 103-105.
Abstract: In the present study we evaluated campthotecin (CPT)-induced chromosomal damage in human lymphocytes in the G0 phase of the cell cycle as revealed by the premature chromosome condensation technique. The results obtained here indicate that CPT was able to induce chromosome fragments in the G0 phase of the cell cycle of human lymphocytes as detected in prematurely condensed chromosomes. This result appears to be rather surprising, since the DNA lesions produced by CPT (e.g. 'protein concealed' DNA
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Description: L'articolo é disponibile sul sito dell'editore: http://www.oxfordjournals.org
DOI: 10.1093/mutage/14.1.103
URI: http://hdl.handle.net/2067/1719
ISSN: 0267-8357
Appears in Collections:DABAC - Archivio della produzione scientifica

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