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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1716

Title: Werner’s sindrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle
Authors: Pichierri, Pietro
Franchitto, Annapaola
Mosesso, Pasquale
Proietti De Santis, Luca
Balajee, Adayabalam S.
Palitti, Fabrizio
Keywords: Werner's syndrome
DNA Topoisomerase II inhibitors
Recombination and DNA repair
Chromosomal aberrations
Sindrome di Werner
Inibitori delle Topoisomerasi II
Ricombinazione e riparazione del DNA
Aberrazioni cromosomiche
Issue Date: 2000
Publisher: Elsevier
Citation: Pichierri, P. et al. 2000. Werner’s sindrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle. "Mutation Research. DNA Repair" 459(2):123-133
Abstract: Werner's syndrome (WS) is a rare autosomal recessive human disorder and the patients exhibit many symptoms of accelerated ageing in their early adulthood. The gene (WRN) responsible for WS has been biochemically characterised as a 3'-5' helicase and is homologous to a number of RecQ superfamily of helicases. The yeast SGS1 helicase is considered as a human WRN homologue and SGS1 physically interacts with topoisomerases II and III. In view of this, it has been hypothesised that the WRN gene may a
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Description: L'articolo é disponibile sul sito dell'editore: http://www.sciencedirect.com
DOI: 10.1016/S0921-8777(99)00065-8
URI: http://hdl.handle.net/2067/1716
ISSN: ISSN: 0027-5107
Appears in Collections:DABAC - Archivio della produzione scientifica

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