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Please use this identifier to cite or link to this item: http://hdl.handle.net/2067/1715

Title: Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage.
Authors: Pichierri, Pietro
Franchitto, Annapaola
Mosesso, Pasquale
Palitti, Fabrizio
Keywords: Werner’s syndrome
Campthotecin
Transcription
Sindrome di Werner
Camptotecina
Trascrizione
Issue Date: 2000
Publisher: Elsevier
Citation: Pichierri, P. et al. 2000. Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage. "Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis" 456(1-2): 45-57
Abstract: Werner's syndrome (WS) is a recessive human genetic disorder associated with an elevated incidence of many types of cancer. The WS gene product, WRNp, belongs to the RecQ family of DNA helicases and is required for the maintenance of genomic stability in human cells. A possible interaction between helicases and topoisomerases that could co-operate in many aspects of DNA metabolism such as progression of the replication forks, recombination and repair has been recently suggested. In addition, sgs
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Description: L'articolo é disponibile sul sito dell'editore: http://www.sciencedirect.com
URI: http://hdl.handle.net/2067/1715
ISSN: 0027-5107
Appears in Collections:DABAC - Archivio della produzione scientifica

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